Characteristics and outcome of transient ischemic attack and cognitive impairment in minor stroke patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To investigate the clinical characteristics and prognosis of cognitive impair ment with transient ischemic attack (TIA)/minor stroke in elderly patients.Methods 115 elderly patients with TIA/minor stroke were enrolled prospectively from January 2015 March 2017,It is divided into two groups,including Non cognitive impairment group (55 cases) and non dementia vascular cognitive impairment (VCIND) group (60 cases),following for 1,3 and 6 months,com pared the clinical characteristics and the score of Montreal cognitive assessment (MoCA) scale.Results The plasma homocysteine level in VCIND group was significantly higher than non cognitive impairment group [(23.38 ± 3.31)μmol/l vs (17.21± 2.10) μmol/l,P＜0.01].The total MoCA score in non cognitive impairment group was 27.46 ± 1.21,VCIND group was 22.21±2.09,the differences between the two groups were statistically significant (P＜0.05).The average score of visual space/executive ability,delayed memory,language and abstract ability in VCIND group was lower than non cognitive impairment group (P＜0.05,P＜0.01).1,3 and 6months follow-up of group VCIND,The rate of cognitive improvement was 8.3％,33.3％ and 61.7％ (P＜0.05).Conclusion cognitive impairment in elderly patients with TIA and minor stroke is mainly manifested in the visual space/executive ability,delayed recall,language fluency/repetition and abstraction,the cognitive impairment of patients will improve over time.