Relationship between serum homocysteine level and first-ever cardiocerebral vascular events in elderly hypertension-free population / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship between serum homocysteine (Hey) level and firstever cardiocerebral vascular events in elderly hypertension-free population.Methods A total of 6124 hypertension-free patients aged 60-80 years admitted to our hospital for physical examination were randomly divided into control group (n=4122) with their Hcy≤13 μmol/L and experimental group (n=2002) with their Hcy＞13 μmol/L.Their serum Hcy levels were measured.The patients were followed up for 3 years,during which the incidence of first-ever cardiocerebral vascular events was recorded every 6 months and compared.Results No significant difference was found in sex,age,smoking,BMI,SBP,DBP,FBG and LDL-C between the two groups (P＞0.05).The serum Hcy level was significantly higher in experimental group than in control group (29.68±12.87 μmol/L vs 8.12 ± 4.36 μmol/L,P =0.001).The incidence of cardiocerebral vascular events,cerebral infarction and non-lethal myocardial infarction was significantly higher in experimental group than in control group at the end of 3-year follow-up period (18.8％ vs 10.2％,P=0.001;9.0％ vs 4.6％,P=0.025;5.8％ vs 3.0％,P=0.034).Multivariate Cox harzards regression analysis showed that serum Hcy level was an independent risk factor for first-ever cardiocerebral vascular events in elderly hypertension-free population (β=0.78,95 ％ CI1.76-4.12,P =0.003).Conclusion Elevated serum Hcy level is a risk factor for first-ever cardiocerebral vascular events,especially for cerebral and myocardial infarction in elderly hypertension-free population.