The effectiveness of Beraprost sodium in elderly patients with diabetic peripheral neuropathy and its influence on serum nitric oxide and endothelin-1 levels / 中华老年医学杂志

ABSTRACT

Objective To evaluate the effectiveness of Beraprost sodium and its impact on vascular endothelial dysfunction in elderly patients with diabetic peripheral neuropathy (DPN).Methods A total of 86 elderly patients (age≥60 years) with DPN were recruited and randomly assigned into a control group (n=43) and a treatment group (n=43).Both groups received regular treatments including drug treatment such as glucose-lowering,lip-lowering,anti-platelet and neurotropic medications,and non-drug treatment measures such as smoking cessation and foot massage.In addition,the treatment group was given 40 μg oral Beraprost sodium three times a day for 90 days.Data on vibrating perception threshold (VPT),transcutaneous oxygen (tcpO2),ankle-brachial index (ABI),liver and kidney function,hemoglobin A1c (HbA1c),serum nitric oxide (NO) and endothelin-1 (ET-1) were collected before and after treatment.Results No adverse reaction was observed during the experiment.After 90-day treatment,both the control group and the treatment group showed decreased VPT values (F =23.06,195.13,both P ＜0.01),increased tcpO2 values (F =304.65,594.33,both P＜0.01),increased ABI (F=119.24,336.60,both P＜0.01),increased serum NOlevels (F =375.48,741.20,both P＜0.01),and decreased serum ET-1 levels (F=49.07,211.24,both P＜0.01).Compared with the control group,the value of VPT (F=25.16,P＜0.01)and the level of ET-1(F=61.83,P＜0.01) were significantly lower,while the level of NO and the values of tcpO2 and ABI were significantly higher (F =24.06,62.82,21.46,all P ＜ 0.01) in the treatment group.Conclusions Oral beraprost sodium can be effectively and safely used in DNP patients,and it can also alleviate endothelial dysfunction.