Epoxyeicosatrienoic acids and metabolic syndrome :a literature review / 中华老年医学杂志

ABSTRACT

Metabolic syndrome including four components of central obesity ,hypertension , dyslipidemia ,and hyperglycemia ,is a complex syndrome. Along with the improvement of life conditions and population aging ,elderly people become a high risk population for metabolic syndrome , in whom the risks for cardio-and cerebro-vascular events are obviously increased. For the past few years ,epoxyeicosatrienoic acids (EETs)are found to improve patient's condition of hypertension , myocardial ischemia ,and atherosclerosis.Moreover ,EETs can up-regulate HO-1 expression.EETs and HO-1 interaction attenuates inflammatory response and oxidative stress ,regulates vascular endothelial function ,enhances insulin sensitivity ,and improves insulin resistance. This review takes aim at providing a new approach to diagnosis of ,and a new target for therapeutic intervention of metabolic syndrome.