Value of interferon-γ release assays in early diagnosis of pneumoconiosis complicated with tuberculosis / 中华老年医学杂志

ABSTRACT

Objective To investigate the value of interferon-γ release assays(IGRAs)in early diagnosis of pneumoconiosis complicated with tuberculosis.Methods The retrospective study analyzed the results of IGRAs of 498 patients with pneumoconiosis at our hospital from January 2016 to December 2017.The results were compared with those of 1176 non-pneumoconiosis patients.Results The rate of positive IGRAs in patients with pneumoconiosis who had symptoms of respiratory infection was 33.73％,significantly higher than that in non-pneumoconiosis patients (23.64％)(x2 =18.24,P＜0.0001).In pneumoconiosis patients with tuberculosis,the rate of positive IGRAs was 95.35 ％,and in pneumoconiosis patients without tuberculosis,the rate was 89.13 ％ (x2=0.48,P=0.49).The rates of positive IGRAs in patients with stage Ⅱ and stage Ⅲ pneumoconiosis were significantly higher than those in the patients with stage Ⅰ pneumoconiosis,and they increased with the progression of pneumoconiosis (x2 =2.21,P =0.023).Conclusions IGRAs offer added diagnostic value in early diagnosis of pneumoconiosis complicated with tuberculosis.