The glucocerebrosidase gene and Parkinson's disease / 中华老年医学杂志

ABSTRACT

Parkinson's disease(PD) is a common neurodegenerative disease afflicting many older individuals.To date,mutations in the GBA gene is considered as a major risk factor for PD,but the underlying mechanism is still unclear.Glucocerebrosidase (GCase) encoded by GBA may work as a biomarker for the early diagnosis of PD associated with GBA mutations (PD-GBA).Increasing GCase enzyme activity or reducing its substrate availability may protect the neuron and slow the progression of PD-GBA.