Effect of flurbiprofen axetil pretreatment on mesenteric traction syndrome in elderly patients under-going abdominal surgery / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the effect of flurbiprofen axetil pretreatment on mesenteric trac-tion syndrome in elderly patients undergoing abdominal surgery. Methods Sixty patients of both sexes, aged 65-86 yr, with body mass index of 18.8-25.6 kg∕m2, of American Society of Anesthesiologists phys-ical status Ⅰor Ⅱ, scheduled for elective gastrointestinal tract surgery under general anesthesia, were di-vided into 2 groups(n=30 each)using a random number table flurbiprofen axetil group(group F)and normal saline group(group NS). Flurbiprofen axetil 50 mg was intravenously injected during anesthesia in-duction in group F, while the equal volume of normal saline was given instead in group NS. Immediately af-ter anesthesia induction, immediately after mesenteric traction and at 10, 15 and 30 min after mesenteric traction, arterial blood samples were collected for measurement of plasma 6-keto-prostaglandin F1α concen-trations using enzyme-linked immunosorbent assay. The occurrence of mesenteric traction syndrome was re-corded within 30 min after mesenteric traction. Results Compared with group NS, the plasma 6-keto-pros-taglandin F1α concentrations were significantly decreased at each time point, and the incidence of mesen-teric traction syndrome was decreased during each period after mesenteric traction in group F(P<0.05). Conclusion Flurbiprofen axetil pretreatment can effectively prevent the development of mesenteric traction syndrome in elderly patients undergoing abdominal surgery.