Simultaneous determination of eleven constituents in Huxin Oral Liquid by LC-MS/MS / 中成药
Chinese Traditional Patent Medicine
;
(12): 105-109, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-710163
ABSTRACT
AIM To establish a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous content determination of matrine,oxymatrine,salvia acid B,tanshinol,protocatechualdehyde,liquiritin,astragaloside,cinnamaldehyde,tanshinone Ⅱ A,ophiopogonin D and ruscogenin in Huxin Oral Liquid (Glycyrrhizae Radix et Rhizoma,Astragali Radix,Ophiopogonis Radix,etc.).METHODS The analysis of methanol extract of this drug was performed on a 25 ℃ thermostatic Ultimate XB-C18 column (4.6 mm × 100 mm,3 μm),with the mobile phase comprising of water-methanol (containing 0.05% formic acid) flowing at 0.4 mL/min in a gradient elution manner.RESULTS Eleven constituents showed good linear relationships with-in their own ranges (r >0.999 0),whose average recoveries were 96.66%-103.2% with the RSDs of 1.4%-3.4%.CONCLUSION This sensitive,reliable and accurate method can be used for the quality control of Huxin Oral Liquid.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Traditional Patent Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS