Application of Nalbuphine in Postoperative Analgesia After Uterine Artery Embolization / 中国微创外科杂志

ABSTRACT

Objective To explore the safety and feasibility of application of nalbuphine in uterine artery embolization. Methods We selected 70 cases of gynecologic fibroids receiving interventional surgery from January 2015 to October 2016 in our hospital.According to random number table,they were divided into either experimental group or control group,with 35 cases in each group.After selective uterine artery embolization,conventional intravenous analgesia pump was used to relieve pain.The experimental group was given nalbuphine 1 mg/kg and flurbiprofen 100 mg,and the control group was given sufentanil 2 μg/kg and flurbiprofen 100 mg.The visual analogue scale(VAS), nausea and vomiting, respiratory depression and other complications were observed in both groups after operation at 2,6,12,24 and 48 h. Results There were no significant differences between two groups at each time point after surgery in VAS scores[2 h(4.2 ±0.7)points vs.(4.0 ±0.5)points,t=1.375,P=0.174;6 h(3.5 ±0.4)points vs.(3.3 ±0.6)points,t=1.641,P=0.105;12 h(3.0 ±0.7)points vs.(2.8 ±0.5)points, t=1.375, P=0.174;24 h(2.8 ±0.5)points vs.(2.6 ±0.6)points,t=1.515,P=0.134].At 48 h after operation,the VAS score was significantly higher in the control group than that in the experimental group[(2.3 ±0.3)points vs.(2.1 ±0.4)points, t=2.366, P=0.021].The incidence of nausea in the experimental group was lower than that in the control group(22.9%vs.2.9%,χ2=4.590,P=0.032). Conclusion Use of nalbuphine for analgesia after uterine artery embolization has good analgesic results and reduces the incidence of nausea and vomiting after operation.