Influence of hyperthermic intraperitoneal perfusion chemotherapy on cellular immune function in esophagogastric junction adenocarcinoma after radical resection / 中华普通外科杂志
Chinese Journal of General Surgery
;
(12): 1047-1049, 2017.
Article
in Chinese
| WPRIM
| ID: wpr-710482
ABSTRACT
Objective To evaluate T lymphocyte changes in esophagogastric junction adenocarcinoma (AEGJ) patients receiving early hyperthermic intraperitoneal perfusion chemotherapy (HIPEC) after radical resection.Methods 98 AEGJ cases were randomized into postoperative early paclitaxel HIPEC group (50 cases) and surgery only group (48 cases).The changes in TLC,CD3 +,CD4 +,CD8 + and CD4 + CD25 + were examined by using flow cytometry on the preoperaive d1,and on the postoperative d 9.Results There were significant differences in cellular ratios of TLC,CD3 +,CD4 +,CD8 + and CD4 + CD25 + between the two groups on postoperative d 9 [(1.85 ± 0.36) × 109/L,(1.28 ± 0.28) ×109/L,t=8.727,P<0.001;76% ±6%,65% ±6%,t =8.680,P<0.001;57% ±8%,41% ± 7%,t =10.246,P <0.00120% ±7%,25% ±6%,t =4.037,P <0.001;4.2% ±1.8%;6.7% ± 2.0%,t =6.548,P < 0.001].Conclusion Postoperative early HIPEC using paclitaxel improves the celluar immune activity of T cell subsets in advanced AEGJ patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Controlled clinical trial
Language:
Chinese
Journal:
Chinese Journal of General Surgery
Year:
2017
Type:
Article
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