A comparison of the Lille Apathy Rating Scale-informant, the Apathy Evaluation Scale-Informant, and the Neuropsychiatric Inventory-Apathy Subscale in mild cognitive impairment informants / 中华神经科杂志

ABSTRACT

Objective To compare the Lille Apathy Rating Scale-informant (LARS-i),the Apathy Evaluation Scale-Informant (AES-I) and the Neuropsychiatric Inventory-Apathy Subscale (NPI-Apathy) in mild cognitive impairment (MCI) informants.Methods Data were collected from 181 informants of patients with MCI by the LARS-i,AES-I and NPI-Apathy scales.The evaluation results by the three scaleswere analyzed by correlation analysis and receiver operating characteristic (ROC) curve.Results By the Chinese versions of the LARS-i and AES-I scales,the best ROC curve was at a cutoff score of-16,33 respectively for a prediction of apathy (with sensitivity of 72.00％,75.31％ respectively,and specificity of 65.38％,75.76％ respectively).The scores of the LARS-i and AES-i scales (r =0.566,P ＜0.01),and the scores of AES-I and NPI-Apathy scales (r =0.388,P ＜ 0.01) were positively correlated.The AES-I and NPI-Apathy scores were positively correlated with the scores of the Geriatric Depression Scale (r =0.250,0.169,P＜0.05),while the score of the LARS-i scale not.The scores of LARS-i,AES-I scales were negatively correlated with the score of MoCA scale (r =-0.232,-0.239,P ＜ 0.01),whereas the NPI-Apathy score had no correlation with the MoCA score.The AES-I and LARS-i scales reported greater apathy compared to that reported by the NPI-Apathy scale,with cases of 94,81,25 respectively.Conclusions The results of the Chinese versions of LARS-i and AES-I scales are similar,which are better than the NPI-Apathy scale in MCI informants in China.And the LARS-i scale can distinguish between apathy and depression to a certain extent.