The risk factors of mortality in peritoneal dialysis patients in different periods / 中华肾脏病杂志

ABSTRACT

Objective To explore the risk factors and characteristics in patients with peritoneal dialysis who died in different periods.Methods The clinical data of new peritoneal dialysis patients in the Department of Nephrology and Peritoneal Dialysis Center of the First Affiliated Hospital of Nanchang University from November 1,2005 to February 28,2017 was retrospectively analyzed.The patients were divided into two groups according to the time of deaththose who died within one year and died after one year.The risk factors of mortality between the two groups were analyzed by Cox regression model.Results A total of 997 patients were enrolled and 244 patients died.There were 69 patients (28.3％) died within one year and 175 patients (71.7％) died after one year.Cardiovascular and cerebrovascular disease was the dominating reason of death in both groups,accounting for 59.4％ (died within one year group) and 51.4％ (died after one year group) respectively.Cox regression analysis showed that for died within one year group,old age (HR=1.035,95％ CI1.016-1.055,P＜ 0.001),low blood total calcium (HR=0.167,95％ CI0.053-0.529,P=0.002),low albumin (HR=0.899,95％CI0.856-0.943,P ＜ 0.001) and low apolipoprotein A1 (HR=0.274,95％CI0.095-0.789,P=0.016) were risk factors associated with mortality.However,for died after one year group,old age (HR=1.053,95％CI1.038-1.069,P ＜ 0.001),combined with diabetes (HR=2.181,95％CI1.445-3.291,P ＜ 0.001) and hypertriglyceride (HR=l.204,95％CI1.065-1.362,P=0.003) were risk factors associated with mortality.Conclusions The risk factors of mortality for peritoneal dialysis patients of different periods were not exactly the same.For died within one year patients,old age,low blood total calcium,low albumin and low apolipoprotein A1 were independent risk factors for mortality.However,for died after one year patients,old age,combined with diabetes,and high triglycerides were independent risk factors for mortality.