Gut-microbiota-brain axis: implications and progress in neonatology / 中华围产医学杂志

ABSTRACT

Growing evidence from animal experiments and human epidemiological studies has revealed the intriguing communications between the gut,microbiota and brain,i.e.,the gut-microbiota-brain axis.The microbiota establishes its symbiotic rapport with the host early in life and participates in multiple developmental and physiological processes,including regulating brain development and influencing behavior and neurological function.Multiple perinatal factors influence neonatal colonization,and gut dysbiosis is a common finding in preterm infants.Perturbations in the delicate synergetic gut-microbiota-brain communication may have serious consequences,leading to abnormal brain development and long-term neurodevelopment disorders.