Advances in diagnostic criteria and biomarkers for neonatal acute kidney injury / 中华围产医学杂志

ABSTRACT

Acute kidney injury (AKI) has a high incidence in neonates. A variety of perinatal factors may contribute to neonatal AKI, resulting in short- and long-term adverse outcomes, including chronic kidney disease. Early diagnosis and timely treatment can significantly improve the outcomes of these babies. Diagnostic criteria for AKI in adults and children are inapplicable to neonates due to the specific pathophysiological characteristics in newborns. In addition, current diagnosis criteria for neonatal AKI are still inconsistent. These all make it more difficult to diagnose neonatal AKI accurately. New biomarkers for kidney injury, such as neutrophil gelatinase-associated lipocalin, kidney injury molecule-1 and interleukin-18, have been found valuable for early and accurate diagnosis and prognosis of neonatal AKI. However, more studies are required to clarify the influencing factors, diagnostic values and clinical significance of those biomarkers.