Experimental Glaucoma Induced by The Use of Alpha-Chymotrypsin

ABSTRACT

Glaucoma was attempted to induce in rabbits by the injection of alpha-chymotrysin into the poster ior chamber. The enzyme solution, 80 units and 375 units, dissolved in 0.2 ml, were used and the changes in the intraocular pressure were recorded. Of 7 eyes injected with 80 units, three eyes showed moderate elevations which lasted 4 to 7 days. Of 3 eyes which received 375 units solution, two eyes showed moderate rise in the intraocular pressure with the duration of 2 to 4 days. There can be found nothing characteristic for the glaucoma...cupping of the disk and degeneration of the optic nerve fiber, etc...in eyes with elevated intraocular pressure. The possible explanations of these transient rise in the intraocular pressure were discussed.