Follicular helper T cells in systemic lupus erythematosus: a review / 中华微生物学和免疫学杂志
Chinese Journal of Microbiology and Immunology
;
(12): 73-78, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-711370
ABSTRACT
Systemic lupus erythematosus (SLE) is a severe systemic autoimmune disease, which is characterized by excessive production of autoantibodies caused by B cell hyperactivity. Thus,reducing au-toantibody production can control the development of SLE,and understanding the molecular and cellular fac-tors involved in the differentiation of B cells will provide new therapeutic targets. Follicular helper T cells (Tfh) are defined as a new subset of CD4+T cells specialized in providing help to B cells,which is suspec-ted to play a critical role in the pathogenesis of SLE. In the present review,we give an overview of key mole-cules involved in the differentiation,regulation and functions of Tfh,discuss the roles of Tfh in SLE and de-scribe some potential therapeutic targets for SLE.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Microbiology and Immunology
Year:
2018
Type:
Article
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