Progress in plasmid-mediated colistin resistance gene mcr-1 / 中华微生物学和免疫学杂志

ABSTRACT

Colistin has been revalued as the last resort for multi-drug resistant gram-negative bacte-ria infections and attracted considerable attention. The plasmid-mediated colistin resistance gene mcr-1 was first reported in 2005,which not only altered our understanding of the mechanisms of colistin resistance,but also posed a significant threat to public health. Until now,mcr-1 has been reported in more than 30 countries and regions spreading over five continents. The whole world has paid high attention to mcr-1 and taken meas-ures to control the administration of colistin in order to contain the spread and dissemination of mcr-1. This review focused on the structure,epidemiology and molecular biological characteristics of mcr-1 and measures for the prevention of mcr-1 spreading,aiming at enhancing the recognition,prevention and control of mcr-1.