Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA
Nutrition Research and Practice
;
: 326-330, 2008.
Article
in English
| WPRIM
| ID: wpr-71162
ABSTRACT
Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sensitivity and Specificity
/
Colonic Neoplasms
/
Linoleic Acid
/
Models, Animal
/
Endothelial Cells
/
Linoleic Acids, Conjugated
/
Macrophages
Type of study:
Diagnostic study
Language:
English
Journal:
Nutrition Research and Practice
Year:
2008
Type:
Article
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