Role of vascular endothelial growth factor in the pathogenesis of traumatic proliferative vitreoretinopathy / 中华眼底病杂志

ABSTRACT

Proliferative vitreoretinopathy (PVR) is a common complication and major cause of blindness of ocular trauma.Many cytokines,including vascular endothelial growth factor (VEGF) and plateletderived growth factor (PDGF),participate in the process of the pathogenesis of traumatic PVR.VEGF competitively inhibits binding of PDGF to its receptor (PDGFRα),enables indirect activation of PDGFRα by non-PDGF ligands,resulting in reduced p53 expression,cell proliferation and migration,which is a key point in the pathogenesis of traumatic PVR.