Choroidal nevus / 中华眼底病杂志

ABSTRACT

Choroidal nevus is one of the most common benign melanocytic tumor.The prevalence rate of choroidal nevi is 0.15％-10.00％,which is high among whites and low among colored people,and is obvious higher in male than that in female.Secondary changes in the surrounding retina of the benign tumor,such as subretinal fluid and choroidal neovascularization,may result in vision loss.This benign tumor carries risks for transformation into malignant melanoma.The factors predictive of transformation into melanoma included greater thickness,subretinal fluid,visual symptoms,orange lipofuscin pigment,tumor location (tumor margin near optic disc),ultrasonography hollowness and absence of halo.Early identification of the related features which impair visual acuity is important for early treatment and better prognosis,and it is especially important to monitor the tendency of malignant transformation.Optical coherence tomography (OCT) could provide detailed information which aid in diagnosing,differentiating and monitoring of choroidal nevi.OCT and optical coherence tomography angiography are emerging as excellent techniques to investigate choroidal melanocytic lesions.The treatment modalities,such as laser photocoagulation,photodynamic therapy and intravitreal anti-vascular endothelium growth factor,have been proved to be effective for choroidal nevi with secondary changes.In the future,the relevant researches should be imposed to provide more detailed information in order to explore the nature and characteristics of this disease.