Advanced studies on the role of Slit2-Robo signaling in angiogenesis of fundus oculi and some other organs / 中华眼底病杂志
Chinese Journal of Ocular Fundus Diseases
;
(6): 308-311, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-711923
ABSTRACT
Axon guidance molecules,slit glycoprotein (Slit) and Roundabout receptors (Robo) were firstly identified in the central neural system of Drosophila melanogaster.The Slit-Robo signal plays a crucial role in axon guidance,inflammation,tumor metastasis and angiogenesis,of which the role of Slit2-Robo pathway in angiogenesis has drawn a greater attention and still remains conflicting.Herein,we provide a review on the role of Slit2-Robo pathway in ocular angiogenesis and vascularization of other organs and systems.We hope this review will be the basis of further study on the mechanism of Slit2-Robo signaling on angiogenesis and provide new target for the therapy on ocular vascular disease
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Practice guideline
Language:
Chinese
Journal:
Chinese Journal of Ocular Fundus Diseases
Year:
2018
Type:
Article
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