Advances of stem cell transplantation in the treatment of retinal degeneration / 中华眼底病杂志

ABSTRACT

Retinal degeneration mainly include age-related macular degeneration,retinitispigmentosa and Stargardt's disease.Although its expression is slightly different,its pathogenesis is photoreceptor cells and/or retinal pigment epithelial (RPE) cel 1 damage or degeneration.Because of the 1 ack of self-repairing and renewal of retinal photoreceptor cells and RPE cells,cell replacement therapy is one of the most effective methods for treating such diseases.The stem cells currently used for the treatment of retinal degeneration include embryonicstem cells (ESC) and various adult stem cells,such as retinal stem cells (RSC),induced pluripotent stem cells (iPSC).and mesenchymal stem cells (MSC).Understanding the currentbasic and clinical application progress ofESC,iPSC,RSC,MSC can provide a new idea for the treatment of retinal degeneration.