Changes of serum neutrophil chemotactic activity(NCA) and myeloperoxidase(MPO) level following lysine-aspirin(L-ASA) bronchoprovocation test in aspirin-sensitive asthmatic patients / 천식및알레르기
Journal of Asthma, Allergy and Clinical Immunology
;
: 181-187, 1999.
Article
in Korean
| WPRIM
| ID: wpr-71225
ABSTRACT
BACKGROUND:
There have been few reports suggesting involvement of mast cell and neutrophil to induce bronchoconstriction in aspirin-sensitive asthrna.OBJECTIVE:
To evaluate mast cell and neutrophil activation in pathogenesis of aspirin-sensitive asthma. MATERIAL ANDMETHOD:
We observed changes of serum NCA and MPO levels during L-ASA bronchoprovocation test in 14 subjects with aspirin-sensitive asthma.RESULTS:
Serum NCA was significantly increased at 30 min(p=0.01) after the inhalation of L-ASA and then, no significant changes were noted at 240 min (p=0.14). NCA was significantly higher in subjects with late asthmatic responses than in those without it (p=0.04). Serum MPO level tended to increase at 30 min with no statistical significance (p=0.08), and then it significantly decreased at 240 min (p=0.05). There was no significant correlation between serum NCA and MPO level (r=0.22, p=0.58).CONCLUSION:
These results support the view that NCA derived from mast cell may contribute to neutrophil recruitment into the airway in aspirin-sensitive asthmatic patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Inhalation
/
Bronchoconstriction
/
Neutrophil Activation
/
Neutrophil Infiltration
/
Mast Cells
/
Neutrophils
Type of study:
Diagnostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of Asthma, Allergy and Clinical Immunology
Year:
1999
Type:
Article
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