Effect of Latanoprost on the Cultured Human Uveal Melanocytes
Journal of the Korean Ophthalmological Society
;
: 893-897, 2001.
Article
in Korean
| WPRIM
| ID: wpr-71254
ABSTRACT
PURPOSE:
To investigate the effect of latanoprost on the melanogenesis and endogenous PG release.METHODS:
Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week.RESULTS:
After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05).CONCLUSIONS:
These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Hydrocortisone
/
Dinoprost
/
Indomethacin
/
Melanins
/
Melanocytes
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2001
Type:
Article
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