Progress of gastric cancer stem cells / 肿瘤研究与临床

ABSTRACT

Gastric cancer ranks the third mortality of tumors around the world. The major influencing factors include genetic factors, ionizing radiation, chemical carcinogens, helicobacter pylori, environment and diet, leading to over-expression of oncogene and down-regulation of tumor-suppressor gene and resulting in abnormal proliferation of cancer cells even cancer. With the in-depth research, it has shown that the cancer stem cell plays an important role in the occurrence and development of gastric cancer, and it has indicated that the occurrence of gastric cancer may be associated with diseases related to stem cell. This paper reviews the characteristics, source, identification, separation methods, markers, and signal pathways of gastric cancer stem cells.