Progress of vimentin in gynecological malignant tumors / 肿瘤研究与临床

ABSTRACT

Vimentin, a kind of type Ⅲ intermediate filament protein, is the major component of cytoskeleton of stromal cells. Increasing researches have demonstrated that vimentin is over-expressed in muiltple tumor tissues, and is closely related with the occurrence, development, invasion and metastasis of tumors. However, correlated studies including cervical neoplasm, endometrial neoplasm and ovarian neoplasm start comparatively late with inconsistent conclusions, thus, a lot of mechanisms need to be further investigated. This paper reviews the expressions and the clinical significances of vimentin in 3 kinds of gynecological malignant tumors.