Distribution analysis of body mass index in 1 005 patients with thyroid cancer / 肿瘤研究与临床

ABSTRACT

Objective To analyze the distribution of body mass index (BMI) in the patients with thyroid cancer. Methods The clinical data of 1 005 cases of thyroid cancer diagnosed by the postoperative pathology from January 2007 to October 2017 in Xinjiang Military Region General Hospital were retrospectively analyzed. A total of 668 healthy people who underwent ulltrasonic and functional test of thyroid cancer without obvious abnormal response were chosen as healthy controls. The preoperative BMI of thyroid cancer patients and BMI distribution of healthy controls were compared. Results According to the BMI Asia criteria, 1 005 patients with thyroid cancer included 346 (34.43 %) cases of obesity, 296 (29.45 %)normal cases, 275 (27.36 %) chubby cases, 60 (5.97 %) cases of severe obesity, 28 lean cases and the obese people were the most. Among 668 healthy controls, 269 (40.27 %) cases were normal, 168 (25.15 %) cases were chubby, 165 (24.70 %) cases were obesity, and 41 (6.14 %) cases were lean, 25 (3.74 %) cases were severe obesity and the most common was the normal group. There was a statistically significant difference of BMI distribution between the two groups in the lean, normal, obesity, and severe obesity group (χ2= 11.400, P = 0.001; χ 2= 20.991, P = 0.000; χ 2= 17.898, P = 0.000; χ 2= 4.129, P = 0.042). The pathological types of 1005 cases of thyroid cancer were mainly papillary carcinoma [948 cases (94.33 %)], successively followed by follicular carcinoma [42 cases (4.18 %)], medullary carcinoma [9 cases (0.90 %)] and undifferentiated carcinoma [6 cases (0.60 %)]. Patients with papillary carcinoma included 321 (33.86 %) obese cases, 282 (29.75 %) normal cases, 264 (27.85 %) chubby cases, 57 (6.01 %) cases of severe obesity, and 24 (2.53 %) lean cases. Patients with follicular carcinoma included 19 cases (45.24 %) obese cases, 9 (21.43 %) normal cases, 7 (16.67 %) chubby cases, 4 (9.52 %) lean cases, and 3 (7.14 %) cases of severe obesity; Patients with medullary carcinoma included 4 obese cases, 3 chubby cases, and 2 normal cases; Patients with undifferentiated cancer included 3 normal cases, 2 obese cases, and 1 chubby case. There was no significant difference in BMI distribution among different pathological types of thyroid cancer patients (all P＞ 0.05). Conclusions The number of obesity and severe obesity in thyroid cancer patients is more than that in healthy people, while the number of lean and normal groups is less than that in healthy controls. Obesity may be related with thyroid cancer, which contributes to the risk assessment and prevention of thyroid cancer.