Relationship between DNA methylation and digestive system malignant tumors / 肿瘤研究与临床

ABSTRACT

DNA methylation refers to the use of S-adenosylmethionine as a methyl donor(SAM),in the role of DNA methyltransferases(DNMT),the methyl group added 5-methylcytosine(5-mC)was formed on the cytosine of 5'terminal CpG dinucleotide.DNA methylation is one of the common epigenetic events,play a key role in the diagnosis and treatment of tumors,increasingly become a hot topic of related tumors.Digestive system tumors is the main cause of cancer-related death worldwide,and there is a lack of early diagnosis.This article provides a brief overview of the relationship between DNA methylation and digestive system malignant tumors.