The Effect of High Dose Methotrexate loaded Acrylic Cement in Type II Collagen Induced Arthritis in Rats / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 61-68, 2002.
Article
in Korean
| WPRIM
| ID: wpr-71295
ABSTRACT
PURPOSE:
We had examined the effect of high dose MTX loaded acrylic cement in the treatment of type II collagen induced arthritis. MATERIALS ANDMETHODS:
we used inbreed rat(16weeks - 20weeks) and divided into control group and experimental groups. inbreed rat was induced arthritis by prepared collagen through injection at the tail base. The control group was injected with collagen only. but the experimental groups were inserted intraperitoneally MTX-loaded acryl cement 25mg, 20mg, 15mg, and 10mg MTX in acrylic cement (0.5gm) respectively. The histopathologic results were investigated to determine the effect of MTX on the 3rd, 7th, 14th, 28th, 42th, and 56th day after inserting high dose MTX loaded acrylic cement which was inserted intraperitoneally 2weeks later of collagenase injectionRESULTS:
The arthritis index of the MTX-loaded groups had reduced than arthritis index of the control group according to the dosage and In histopathological test, the experimental group injected with 15mg, 20mg, and 25mg of MTX had distinctive effects, compared to the control group, as dosage chronologically.CONCLUSION:
The treatment of high-dose MTX loaded acrylic cement might be effective on rheumatoid arthritis managment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arthritis
/
Arthritis, Rheumatoid
/
Tail
/
Methotrexate
/
Collagen
/
Collagenases
/
Collagen Type II
Limits:
Animals
Language:
Korean
Journal:
Journal of Korean Orthopaedic Research Society
Year:
2002
Type:
Article
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