Comparison of Treatment Outcomes for T3 Glottic Squamous Cell Carcinoma: A Meta-Analysis
Clinical and Experimental Otorhinolaryngology
;
: 1-8, 2018.
Article
in English
| WPRIM
| ID: wpr-713337
ABSTRACT
OBJECTIVES:
This study compared the survival outcomes, local control rate, and laryngeal preservation rate of various treatment strategies in the treatment of T3 squamous cell carcinoma of the glottis using proportional meta-analyses.METHODS:
Twenty-five retrospective case-series studies were included in these analyses. Treatment strategies were classified as total laryngectomy (TL), open partial laryngectomy (PL), transoral laser microsurgery (TLM), chemo-radiation therapy (CRT), and radiation therapy (RT) alone.RESULTS:
The overall survival rate and disease-specific survival rate among laryngeal preservation treatments did not differ from the overall survival rate of TL. However, the local control rate was lower with RT than TL and PL, and laryngeal preservation rates of TLM and CRT were higher than RT alone.CONCLUSION:
Consideration of preservation of laryngeal function is necessary when treating T3 glottic squamous cell carcinoma. PL, TLM, and, CRT are considered more appropriate initial laryngeal preservation strategies if available.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Organ Preservation
/
Carcinoma, Squamous Cell
/
Survival Rate
/
Retrospective Studies
/
Epithelial Cells
/
Glottis
/
Laryngectomy
/
Microsurgery
Type of study:
Observational study
/
Systematic reviews
Language:
English
Journal:
Clinical and Experimental Otorhinolaryngology
Year:
2018
Type:
Article
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