Neuroprotective Effect of Duloxetine on Chronic Cerebral Hypoperfusion-Induced Hippocampal Neuronal Damage
Biomolecules & Therapeutics
;
: 115-120, 2018.
Article
in English
| WPRIM
| ID: wpr-713585
ABSTRACT
Chronic cerebral hypoperfusion (CCH), which is associated with onset of vascular dementia, causes cognitive impairment and neuropathological alterations in the brain. In the present study, we examined the neuroprotective effect of duloxetine (DXT), a potent and balanced serotonin/norepinephrine reuptake inhibitor, on CCH-induced neuronal damage in the hippocampal CA1 region using a rat model of permanent bilateral common carotid arteries occlusion. We found that treatment with 20 mg/kg DXT could attenuate the neuronal damage, the reduction of phosphorylations of mTOR and p70S6K as well as the elevations of TNF-α and IL-1β levels in the hippocampal CA1 region at 28 days following CCH. These results indicate that DXT displays the neuroprotective effect against CCH-induced hippocampal neuronal death, and that neuroprotective effect of DXT may be closely related with the attenuations of CCH-induced decrease of mTOR/p70S6K signaling pathway as well as CCH-induced neuroinflammatory process.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylation
/
Brain
/
Dementia, Vascular
/
Carotid Artery, Common
/
Cognition Disorders
/
Neuroprotective Agents
/
Models, Animal
/
Ribosomal Protein S6 Kinases, 70-kDa
/
CA1 Region, Hippocampal
/
Duloxetine Hydrochloride
Language:
English
Journal:
Biomolecules & Therapeutics
Year:
2018
Type:
Article
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