The Role of B Cells in Transplantation Rejection / 대한이식학회지
The Journal of the Korean Society for Transplantation
;
: 1-6, 2018.
Article
in English
| WPRIM
| ID: wpr-713610
ABSTRACT
B cells play a role in graft rejection via several mechanisms. Specifically, B cells produce high-affinity antibodies to alloantigens including allogeneic major histocompatibility complex (MHC) with the help of follicular helper T cells. B cells also function as antigen-presenting cells for alloreactive T cells, resulting in the activation of alloreactive T cells. Conversely, the frequency of regulatory B cells increases under inflammatory conditions and suppresses the rejection process. Here, the differential roles of the major B cell subpopulations (B-1, follicular B, marginal zone B, and regulatory B cells) involved in transplantation rejection are discussed together with their interaction with T cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
B-Lymphocytes
/
T-Lymphocytes
/
T-Lymphocytes, Helper-Inducer
/
B-Lymphocytes, Regulatory
/
Graft Rejection
/
Isoantigens
/
Major Histocompatibility Complex
/
Antibodies
/
Antibody Diversity
/
Antigen-Presenting Cells
Language:
English
Journal:
The Journal of the Korean Society for Transplantation
Year:
2018
Type:
Article
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