Successful Treatment of Cisplatin Overdose with Plasma Exchange
Yonsei Medical Journal
;
: 128-132, 2002.
Article
in English
| WPRIM
| ID: wpr-71367
ABSTRACT
We report a 48-year-old man with laryngeal cancer who received a massive cisplatin toxic overdose without intravenous prehydration through an error in prescription. He received 400 mg/m2 of cisplatin over a 4-day period. On day 4, he exhibited a broad range of cisplatin toxicities and emergency plasma exchange was started. From day 5 through 19, he underwent 9 cycles of plasma exchange and his plasma cisplatin concentration decreased from 2,470 ng/ml to 216 ng/ml. He completely recovered without any sequelae. No previous reports exist in the English literature of survival without complication after the administration of such a high cisplatin dosage without prehydration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma Exchange
/
Cisplatin
/
Drug Overdose
/
Middle Aged
/
Antineoplastic Agents
Limits:
Humans
/
Male
Language:
English
Journal:
Yonsei Medical Journal
Year:
2002
Type:
Article
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