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Productivity Loss of Rheumatoid Arthritis Patients according to the Their Stages of the Disease Activity Score
Journal of Rheumatic Diseases ; : 122-130, 2018.
Article in English | WPRIM | ID: wpr-713816
ABSTRACT

OBJECTIVE:

Productivity loss was compared by 3-stage of disease activity and associations between higher disease activity and high productivity loss were identified.

METHODS:

Data were extracted from Rheumatoid Arthritis (RA) Patient-reported Outcomes Research, which enrolled 2,000 RA patients (>20-year) on disease-modifying-antirheumatic-drugs (DMARDs) (≥6-month) from December 2012 to June 2013. This included 1,457 RA patients with the disease activity score (DAS-28-ESR) in their medical charts. Productivity loss in time and indirect cost was estimated using The World Health Organization Health and Work Performance Questionnaire (HPQ). Baseline characteristics and productivity loss outcomes were compared according to DAS-28-ESR groups.

RESULTS:

84.4% were females, 54.2% had low DAS-28-ESR ( 5.1). Patients with moderate to high DAS-28-ESR had higher lost productivity time (LPT) and monthly costs of LPT than those with low DAS-28-ESR (time in hours 110.0±58.4 vs. 132.4±57.2 vs. 71.5±52.0, p < 0.0001; monthly costs of LPT in 1,000 Korean won 1,097±607 vs. 1,302±554 vs. 741±531, p < 0.0001). Multiple regression analyses revealed significant associations with high LPT in high (adjusted odds ratio [OR]=3.87, 95% confidence interval [CI] 2.18∼6.87) and moderate DAS-28-ESR (adjusted OR=1.88, 95% CI 1.41∼2.52) compared to low DAS-28-ESR. In addition, positive associations with high monthly costs of LPT were observed in high (adjusted OR=3.45, 95% CI 1.98∼5.99) and moderate DAS-28-ESR (adjusted OR=1.93, 95% CI 1.43∼2.54) compared to low DAS-28-ESR.

CONCLUSION:

Timely therapeutic strategies should be taken into consideration given that the RA patients with moderate to high DAS-28-ESR showed strong associations with high productivity loss for effective management of RA.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Rheumatoid / World Health Organization / Odds Ratio / Outcome Assessment, Health Care / Efficiency / Work Performance Type of study: Etiology study / Prognostic study Limits: Female / Humans Language: English Journal: Journal of Rheumatic Diseases Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Arthritis, Rheumatoid / World Health Organization / Odds Ratio / Outcome Assessment, Health Care / Efficiency / Work Performance Type of study: Etiology study / Prognostic study Limits: Female / Humans Language: English Journal: Journal of Rheumatic Diseases Year: 2018 Type: Article