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Wolves Trapped in the NETs–The Pathogenesis of Lupus Nephritis
Journal of Rheumatic Diseases ; : 81-99, 2018.
Article in English | WPRIM | ID: wpr-713820
ABSTRACT
Systemic lupus erythematous (SLE) is a systemic autoimmune disease with multi-organ inflammation caused by the production of pathogenic autoantibodies and immune complexes reflecting a global loss of tolerance. Lupus nephritis (LN) is present in approximately 60% of SLE patients and is considered a major predictor of a poor prognosis. To date, many studies utilizing genomics, transcriptomics, epigenetics, metabolomics, and microbiome have been conducted on a range of animal models and lupus patients to understand the pathogenesis of SLE and LN. Collectively, these studies support the concept that LN is caused by increased cell death, which has not been properly dealt with; abnormal innate immunity; hyperactive adaptive immunity; and genetic variants triggered by a range of environmental factors. This review summarizes the results from studies that contributed strongly to elucidating the pathogenesis of SLE and LN, highlighting the immunological and non-immunological mechanisms.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Autoantibodies / Autoimmune Diseases / Lupus Nephritis / Lymphocytes / Cell Death / Apoptosis / Wolves / Models, Animal / Genomics Type of study: Etiology study / Prognostic study Limits: Humans Language: English Journal: Journal of Rheumatic Diseases Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Autoantibodies / Autoimmune Diseases / Lupus Nephritis / Lymphocytes / Cell Death / Apoptosis / Wolves / Models, Animal / Genomics Type of study: Etiology study / Prognostic study Limits: Humans Language: English Journal: Journal of Rheumatic Diseases Year: 2018 Type: Article