Extensive Pituitary Apoplexy after Chemotherapy in a Patient with Metastatic Breast Cancer
Brain Tumor Research and Treatment
;
: 43-46, 2018.
Article
in English
| WPRIM
| ID: wpr-713833
ABSTRACT
Surgery, anticoagulation therapy, pregnancy, and hormone treatments, such as bromocriptine, are well-characterized precipitating factors for pituitary apoplexy. However, whether cytotoxic chemotherapy for systemic cancer could cause pituitary apoplexy has not been investigated. Here, we present a case of a 41-year-old woman who developed a severe headache with decreased visual acuity after intravenous cytotoxic chemotherapy to treat metastatic breast cancer. Preoperative neuroimaging revealed pituitary adenoma with necrosis. Operative findings and pathologic examination concluded extensive necrosis with a small intratumoral hemorrhage in a pre-existing pituitary adenoma. We reviewed two additional previously published cases of pituitary apoplexy after systemic chemotherapy and suggest that cytotoxic chemotherapy may induce pituitary apoplexy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pituitary Neoplasms
/
Pituitary Apoplexy
/
Breast
/
Breast Neoplasms
/
Bromocriptine
/
Visual Acuity
/
Precipitating Factors
/
Drug Therapy
/
Neuroimaging
/
Headache
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
English
Journal:
Brain Tumor Research and Treatment
Year:
2018
Type:
Article
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