Variable Natural Killer Cell Activity in Hematological Malignancies at Diagnosis
Laboratory Medicine Online
;
: 41-51, 2018.
Article
in English
| WPRIM
| ID: wpr-713889
ABSTRACT
BACKGROUND:
Natural killer (NK) cells play a key role in innate immune responses and are an important component of anti-cancer defenses. This study aimed to investigate the clinicopathological characteristics of NK cell activity (NKA) among various hematological malignancies at diagnosis and to evaluate their clinical value as a monitoring marker.METHODS:
A total of 111 patients that were newly diagnosed with hematological malignancies were recruited, comprising 18 acute myeloid leukemia (AML), 31 multiple myeloma (MM), and 62 lymphoma. Twenty-three normal control subjects from our health examination center were recruited. NKA was measured using a commercially available enzyme-linked immunosorbent assay kit, which measures interferon-gamma secreted by ex vivo-stimulated NK cells in whole blood.RESULTS:
The 111 patients had a median NKA of 202.80 pg/mL (range 40–2,000). NKA was significantly decreased in patients with AML (median 47.05 pg/mL, 40–2,000, P<0.0001), MM (275.00, 40–2,000, P<0.0001), and lymphoma (289.49, 40–2,000, P<0.0001) compared with that in normal controls (1,891, 412–2,000). There was a difference in NKA between AML and lymphoma (P=0.0499). Serial changes in NKA correlated with disease progression. NKA did not correlate with the NK cell count in any group of hematological malignancies.CONCLUSIONS:
The measurement of NKA could be useful to evaluate the immunological status in hematological malignancies at diagnosis and during follow-up.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Enzyme-Linked Immunosorbent Assay
/
Killer Cells, Natural
/
Leukemia, Myeloid, Acute
/
Follow-Up Studies
/
Interferon-gamma
/
Disease Progression
/
Hematologic Neoplasms
/
Diagnosis
/
Immunity, Innate
/
Lymphoma
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Laboratory Medicine Online
Year:
2018
Type:
Article
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