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Clinical Outcomes of Proton Beam Therapy for Choroidal Melanoma at a Single Institute in Korea / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment ; : 335-344, 2018.
Article in English | WPRIM | ID: wpr-713899
ABSTRACT

PURPOSE:

This study retrospectively evaluated the clinical outcomes and complications of proton beam therapy (PBT) in a single institution in Korea and quantitatively analyzed the change in tumor volume after PBT using magnetic resonance imaging (MRI). MATERIALS AND

METHODS:

Twenty-four treatment-naïve patients who underwent PBT for choroidal melanoma between 2009 and 2015 were reviewed. Dose fractionation was 60-70 cobalt gray equivalents over 5 fractions. Orbital MRIs were taken at baseline and 3, 6, and 12 months after PBT and annually thereafter. The tumor volume was reconstructed and evaluated by stacking the tumor boundary in each thin-sliced axial T1-weighted image using MIM software.

RESULTS:

The median follow-up duration was 36.5 months (range, 9 to 82 months). One patient had suspicious local progression and two patients had distant metastasis. The 3-year local progression-free survival, distant metastasis-free survival, and overall survival rates were 95.8%, 95.8%, and 100%,respectively. Five Common Terminology Criteria for Adverse Event ver. 4.03 grade 3-4 toxicities were observed in four patients (16.7%), including one with neovascular glaucoma. The mean tumor volume at the baseline MRI was 0.565±0.084 mL (range, 0.074 to 1.610 mL), and the ratios of the mean volume at 3, 6, and 12 months to that at baseline were 81.8%, 67.3%, and 60.4%, respectively.

CONCLUSION:

The local controlrate and complication profile after PBT in patientswith choroidal melanoma in Korea were comparable with those reported in a previous PBT series. The change in tumor volume after PBT exhibited a gradual regression pattern on MRI.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Orbit / Protons / Magnetic Resonance Imaging / Glaucoma, Neovascular / Survival Rate / Retrospective Studies / Follow-Up Studies / Choroid / Treatment Outcome / Cobalt Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Orbit / Protons / Magnetic Resonance Imaging / Glaucoma, Neovascular / Survival Rate / Retrospective Studies / Follow-Up Studies / Choroid / Treatment Outcome / Cobalt Type of study: Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Cancer Research and Treatment Year: 2018 Type: Article