Risk Factors Affecting Adverse Effects of Cyclosporine A in a Real-World Psoriasis Treatment
Annals of Dermatology
;
: 143-149, 2018.
Article
in English
| WPRIM
| ID: wpr-714166
ABSTRACT
BACKGROUND:
No study to date has focused on the changes in laboratory test results and related risk factors in patients with psoriasis treated with prolonged Cyclosporine A (CsA) therapy.OBJECTIVE:
The objective of this study was to investigate the changes of laboratory values and related risk factors in patients with psoriasis treated with CsA in a real-world setting.METHODS:
Records of patients with psoriasis treated with CsA at an outpatient clinic were collected, and a Cox proportional hazards regression model was used.RESULTS:
Of the 128 patients included in this study, 28 patients (21.9%) showed laboratory test abnormalities over a mean medication period of 11.6 months. Older age (hazard ratio [HR], 1.174; 95% confidence interval [CI], 1.068~1.370; p=0.007) and pre-existing kidney disease (HR, 0.008; 95% CI, 0~0.205; p=0.001) significantly increased the risk of renal dysfunction. Male sex was the only significant risk factor for liver enzyme elevation (HR, 0.284; 95% CI, 0.081~0.784; p=0.026) and uric acid abnormality (HR, 0.048; 95% CI, 0~0.372; p=0.046).CONCLUSION:
This is an in-depth analysis of laboratory changes and related risk factors in patients with psoriasis treated with CsA. Liver is the most commonly affected organ of CsA toxicity. Older age, male sex, and presence of kidney disease were risk factors associated with laboratory abnormality during CsA treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psoriasis
/
Uric Acid
/
Risk Factors
/
Cyclosporine
/
Clinical Laboratory Techniques
/
Ambulatory Care Facilities
/
Kidney Diseases
/
Liver
Type of study:
Diagnostic study
/
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Annals of Dermatology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS