Effects of Low- or Moderate-dose Whole Body-X-ray Radiation on the Immune System of C57BL/6 Mice / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
;
: 50-55, 2018.
Article
in English
| WPRIM
| ID: wpr-714198
ABSTRACT
PURPOSE:
Increase in the use of diagnostic imaging or occupational exposure to radiation have brought upon concerns on the safety and biological effects of low- or moderate-dose radiation. However, limited information is available on the effects of low or moderate dose radiation on human health.METHODS:
Using C57BL/6 mice, we aimed to evaluate the biological effects of low- and moderate-dose radiation on the immune system. X-rays was chosen as a radiation source and we analyzed complete blood counts, various lymphocyte subsets and various cytokine levels after single fraction x-ray exposure (0.1 Gy, 1 Gy).RESULTS:
No significant changes in the immunologic parameter of C57BL/6 mice were observed after radiation, except LIX (a cytokine equivalent to human CXCL5), that showed higher level after 0.1 Gy radiation compared to the control.CONCLUSION:
We observed that a single fraction of low or moderate dose of X-ray radiation does not cause significant changes in the immune system of C57BL/6 mice. Further studies are necessary to elucidate the mechanism underlying our results.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiation Dosage
/
Blood Cell Count
/
Diagnostic Imaging
/
Lymphocyte Subsets
/
Occupational Exposure
/
Immune System
Type of study:
Diagnostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Clinical Pediatric Hematology-Oncology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS