Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 474-487, 2018.
Article
in English
| WPRIM
| ID: wpr-714225
ABSTRACT
PURPOSE:
The purpose of this study was to determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer fourth edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses. MATERIALS ANDMETHODS:
PubMed and EMBASE were searched in April, 2016. Two authors independently reviewed and selected cohort studies on the association between very light (≤ 0.5 drink/day), light (≤ 1 drink/day), or moderate drinking (1-2 drinks/day) and the risk of cancer incidence and mortality. A pooled relative riskwith its 95% confidence intervalwas calculated by a random-effects meta-analysis. Main outcome measures were cancer incidence and mortality.RESULTS:
A total of 60 cohort studies from 135 articles were included in the final analysis. Very light drinking or light drinking was not associated with the incidence of most cancers except for female breast cancer in women and male colorectal cancer. Conversely, light drinking was associated with a decreased incidence of both female and male lung cancer significantly and both female and male thyroid cancer marginally significantly. Moderate drinking significantly increased the incidence of male colorectal cancer and female breast cancer,whereas it decreased the incidence of both female and male hematologic malignancy.CONCLUSION:
We found that very light or light alcohol drinking was not associated with the risk of most of the common cancers except for the mild increase in the incidence of breast cancer in women and colorectal cancer in men.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Breast
/
Breast Neoplasms
/
Alcohol Drinking
/
Thyroid Neoplasms
/
Colorectal Neoplasms
/
Incidence
/
Cohort Studies
/
Mortality
/
Outcome Assessment, Health Care
/
Hematologic Neoplasms
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
/
Systematic reviews
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Cancer Research and Treatment
Year:
2018
Type:
Article
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