Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
Journal of the Korean Association of Oral and Maxillofacial Surgeons
;
: 66-72, 2018.
Article
in English
| WPRIM
| ID: wpr-714257
ABSTRACT
OBJECTIVES:
Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review. MATERIALS ANDMETHODS:
We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method.RESULTS:
Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%.CONCLUSION:
Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
Vimentin
/
Survival Rate
/
Disease-Free Survival
/
Diagnosis
/
Diagnostic Errors
/
Melanoma
/
Methods
/
Mouth
Type of study:
Diagnostic study
Language:
English
Journal:
Journal of the Korean Association of Oral and Maxillofacial Surgeons
Year:
2018
Type:
Article
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