Serial Changes of Cytokines in Children with Cerebral Palsy Who Received Intravenous Granulocyte-colony Stimulating Factor Followed by Autologous Mobilized Peripheral Blood Mononuclear Cells
Journal of Korean Medical Science
; : e102-2018.
Article
in En
| WPRIM
| ID: wpr-714361
Responsible library:
WPRO
ABSTRACT
BACKGROUND: This study was performed to assess serial cytokine changes and their clinical impact in children with cerebral palsy (CP) who received granulocyte-colony stimulating factor (G-CSF) followed by infusion of autologous mobilized peripheral blood mononuclear cells (mPBMCs). METHODS: Peripheral blood (PB) samples were collected from 16 CP children at enrollment, and 1 month and 7 months after G-CSF infusion as well as at the end of the study. Cytokine levels were measured by enzyme-linked immunosorbent assays with plasma samples. RESULTS: There were no significant differences in cytokine levels between the mPBMC and placebo groups over 6 months. However, when clinical responders and non-responders were compared, interleukin (IL)-6 (P = 0.050) as well as G-CSF (P = 0.010) were higher in the responders than the non-responders at 1 month, while brain-derived neurotrophic factor (BDNF) (P = 0.030) and insulin-like growth factor (IGF)-1 (P = 0.001) were lower. In addition, BDNF was higher at baseline in the responders than the non-responders (P = 0.030). CONCLUSION: The changes of G-CSF itself, as well as G-CSF-induced cytokines such as IL-6, may be associated with the clinical improvement of neurologic functions. The G-CSF-induced changes of IL-6, BDNF and IGF-1, and BDNF levels before treatment, could be used as prognostic factors in G-CSF trials in CP children.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Plasma
/
Insulin-Like Growth Factor I
/
Enzyme-Linked Immunosorbent Assay
/
Cerebral Palsy
/
Cytokines
/
Granulocyte Colony-Stimulating Factor
/
Interleukins
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Interleukin-6
/
Brain-Derived Neurotrophic Factor
Type of study:
Clinical_trials
/
Prognostic_studies
Limits:
Child
/
Humans
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2018
Type:
Article