Analysis of Adverse Cutaneous Drug Reactions using an Electronic Drug Adverse Reaction Reporting System at a Single Secondary Referral Center: A Retrospective Study / 대한피부과학회지
Korean Journal of Dermatology
;
: 251-258, 2018.
Article
in Korean
| WPRIM
| ID: wpr-714500
ABSTRACT
BACKGROUND:
Adverse cutaneous drug reactions (ACDRs) are common and are responsible for increased morbidity, mortality, and socioeconomic costs.OBJECTIVE:
The purpose of our study was to investigate the common drugs and clinical patterns related to ACDRs using an electronic drug adverse reaction reporting system at a single secondary referral center.METHODS:
We conducted a retrospective analysis of the ACDR database between January 2014 and April 2016 at the Ilsan Paik Hospital.RESULTS:
The study analyzed 320 patients with ACDRs (malefemale ratio=93227; mean age 50.8±17.8 years). Using a Korean causality evaluation algorithm, the percentage of drugs with a possible relationship with ACDRs was calculated to be 50.6%, while the percentage with a probable relationship was 44.7%. Antibiotics (44.0%), radiocontrast media (15.1%), and non-steroidal anti-inflammatory drugs (NSAIDs) (14.3%) were the most commonly implicated drugs. Antibiotics, including cephalosporins (30.6%) and quinolones (10.2%), were responsible for the majority of the ACDRs. Acetic acid (5.9%) and propionic acid (5.9%) derivatives of NSAIDs were also common causative agents. The most common clinical presentations were maculopapular exanthema (33.4%), pruritus (30.9%), and urticaria (25.7%). Severe ACDRs were significantly associated with older age, eosinophilia, and underlying heart and renal diseases (p<0.05).CONCLUSION:
Antibiotics, radiocontrast media, and NSAIDs were identified as common causes of ACDRs. Older age, eosinophilia, heart disease, and renal disease were associated with severe ACDRs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pruritus
/
Urticaria
/
Cephalosporins
/
Anti-Inflammatory Agents, Non-Steroidal
/
Retrospective Studies
/
Mortality
/
Adverse Drug Reaction Reporting Systems
/
Quinolones
/
Acetic Acid
/
Contrast Media
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS