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Clinical Utility of a Diagnostic Approach to Detect Genetic Abnormalities in Multiple Myeloma: A Single Institution Experience
Annals of Laboratory Medicine ; : 196-203, 2018.
Article in English | WPRIM | ID: wpr-714529
ABSTRACT

BACKGROUND:

The identification of genetic abnormalities in patients with multiple myeloma (MM) has gained emphasis because genetics-based risk stratification significantly affects overall survival (OS). We investigated genetic abnormalities using conventional cytogenetics and FISH and analyzed the prognostic significance of the identified additional abnormalities in MM.

METHODS:

In total, 267 bone marrow samples were collected from February 2006 to November 2013 from patients who were newly diagnosed as having MM in a tertiary-care hospital in Korea. The clinical and laboratory data were retrospectively obtained. Cox proportional hazard regression was used to examine the relationship between clinical/genetic factors and survival outcome, using univariate and multivariate models.

RESULTS:

Using conventional cytogenetic analysis and FISH, 45% (120/267) and 69% (183/267) patients, respectively, were identified to harbor genetic abnormalities. In the univariate analysis, the following genetic variables were identified to affect OS abnormal karyotype (P 65 years) (P=0.013) with an HR of 2.505 (95% CI, 1.218–5.151).

CONCLUSIONS:

Our findings highlight the importance of applying a comprehensive approach for detecting genetic abnormalities, which could be closely associated with the prognostic significance of MM.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bone Marrow / Multivariate Analysis / Retrospective Studies / Cytogenetic Analysis / Cytogenetics / Abnormal Karyotype / Korea / Aneuploidy / Multiple Myeloma Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Annals of Laboratory Medicine Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Prognosis / Bone Marrow / Multivariate Analysis / Retrospective Studies / Cytogenetic Analysis / Cytogenetics / Abnormal Karyotype / Korea / Aneuploidy / Multiple Myeloma Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Asia Language: English Journal: Annals of Laboratory Medicine Year: 2018 Type: Article