Diagnostic and prognostic value of proadrenomedullin in neonatal sepsis / 소아과
Korean Journal of Pediatrics
;
: 156-159, 2018.
Article
in English
| WPRIM
| ID: wpr-714565
ABSTRACT
PURPOSE:
Sepsis is a major cause of neonatal morbidity and mortality. Early diagnosis is a major problem because of the lack of specific clinical signs. Therefore, a reliable diagnostic marker is needed to guide the use of antimicrobial agents. The objective of our study was to assess the value of proadrenomedullin (pro-ADM) in establishing the diagnosis and evaluating the prognosis of neonatal sepsis.METHODS:
This study enrolled 60 newborn infants with sepsis proven with positive blood cultures and 30 healthy neonates. Complete blood count, C-reactive protein levels, and pro-ADM levels were obtained from all neonates.RESULTS:
The pro-ADM levels were significantly higher (14.39±0.75 nmol/L) in the sepsis group than in the control group (3.12±0.23 nmol/L). The optimal cutoff value for pro-ADM was 4.3 nmol/L, with a sensitivity of 93.3% and a specificity of 86.7%. The pro-ADM levels were also higher in nonsurvivors (P=0.001).CONCLUSION:
Pro-ADM can be used as a reliable biomarker for neonatal sepsis. High pro-ADM levels were associated with mortality and could be an early indicator of disease outcome.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Blood Cell Count
/
C-Reactive Protein
/
Mortality
/
Sensitivity and Specificity
/
Sepsis
/
Early Diagnosis
/
Diagnosis
/
Anti-Infective Agents
Type of study:
Diagnostic study
/
Prognostic study
/
Screening study
Limits:
Humans
/
Infant, Newborn
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2018
Type:
Article
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