Long-term prenatal stress increases susceptibility of N-methyl-D-aspartic acid-induced spasms in infant rats / 소아과
Korean Journal of Pediatrics
;
: 150-155, 2018.
Article
in English
| WPRIM
| ID: wpr-714566
ABSTRACT
PURPOSE:
Infantile spasms, also known as West syndrome, is an age-specific epileptic seizure. Most patients with this condition also exhibit delayed development. This study aimed to determine the effect of long-term prenatal stress on susceptibility to infantile spasms.METHODS:
We subjected pregnant rats to acute or chronic immobilization stress. Resulting offspring received N-methyl-D-aspartic acid (15 mg/kg, intraperitoneally) on postnatal day 15, and their behaviors were observed 75 minutes after injection. The expression of KCC2 and GAD67 was also determined using immunohistochemistry.RESULTS:
Exposure to long-term prenatal stress increased the frequency of spasms and decreased the latency to onset of spasms compared with offspring exposed to short-term prenatal stress. Expression of KCC2 and GAD67 also decreased in the group exposed to long-term prenatal stress compared with the group exposed to short-term prenatal stress.CONCLUSION:
Our study suggests that exposure to long-term prenatal stress results in increased susceptibility to seizures.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prenatal Exposure Delayed Effects
/
Seizures
/
Spasm
/
Spasms, Infantile
/
Immunohistochemistry
/
N-Methylaspartate
/
Epilepsy
/
Gamma-Aminobutyric Acid
/
Glutamate Decarboxylase
/
Immobilization
Limits:
Animals
/
Humans
Language:
English
Journal:
Korean Journal of Pediatrics
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS