Assessment of Switching to Suvorexant versus the Use of Add-on Suvorexant in Combination with Benzodiazepine Receptor Agonists in Insomnia Patients: A Retrospective Study
Clinical Psychopharmacology and Neuroscience
;
: 184-189, 2018.
Article
in English
| WPRIM
| ID: wpr-714652
ABSTRACT
OBJECTIVE:
Suvorexant is a novel hypnotic drug that does not interact with the conventional γ-aminobutyric acid (GABA)-A receptor. We investigated the method by which suvorexant was introduced in insomnia patients who were taking benzodiazepine receptor agonists (BzRA).METHODS:
This was a retrospective study. We extracted clinical data for patients who were prescribed suvorexant and were already using BzRA. The patients were assigned to two groups, the switching and add-on groups. We assessed the suvorexant discontinuation rate at one month after the prescription of the drug.RESULTS:
One hundred and nineteen patients were assigned to the switching group, and 109 were assigned to the add-on group. The add-on group exhibited a significantly higher all-cause discontinuation rate than the switching group (odds ratio, 2.7; 95% confidence interval, 1.5 to 5.0; adjusted p < 0.001). Intolerability was a significantly stronger risk factor for suvorexant discontinuation in the add-on group (22.0% vs. 7.6%, p < 0.002), and the most common adverse effect was oversedation.CONCLUSION:
Our results show that the add-on of suvorexant increases the frequency of oversedation compared with switching in insomnia patients that are taking BzRA. However, this was only a preliminary retrospective study, and further studies will be required to confirm our findings.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Benzodiazepines
/
Retrospective Studies
/
Risk Factors
/
Receptors, GABA-A
/
Prescriptions
/
Orexin Receptor Antagonists
/
Sleep Initiation and Maintenance Disorders
/
Methods
Type of study:
Etiology study
/
Observational study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Clinical Psychopharmacology and Neuroscience
Year:
2018
Type:
Article
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