BRAF mutation may predict higher necessity of postoperative radioactive iodine ablation in papillary thyroid cancer
Annals of Surgical Treatment and Research
;
: 174-179, 2014.
Article
in English
| WPRIM
| ID: wpr-71471
ABSTRACT
PURPOSE:
The primary aim of the present study was to analyze the association between high-risk clinicopathologic characteristics and the BRAFV600E mutation.METHODS:
From March 2010 to September 2012, we performed analysis of the BRAF mutation (assessing V600E point mutation of BRAF gene, exon 15, on chromosome 7q34 by real-time polymerase chain reaction kit) from 499 papillary thyroid carcinoma (PTC) patients who underwent thyroidectomy. We analyzed the relation between the mutation and known clinicopathologic risk factors of PTC.RESULTS:
BRAF mutations were found in 353 of 499 patients (70.7%). On univariate analysis, BRAF mutations were more frequently detected in patients with central lymph node metastasis (78.5% vs. 66.7%, P = 0.007) and classic PTC type (71.3% vs. 16.7%, P = 0.011). Patients with one or more aggressive pathologic feature such as lymph node metastasis, multifocality, and extrathyroidal extension showed higher BRAF mutation rate (73.5% vs. 62.3%, P = 0.022). BRAF mutation group showed more aggressive pathologic features, which is considered as higher necessity of radioactive iodine ablation (relative risk, 1.617; P = 0.035).CONCLUSION:
This study found that BRAF mutation is associated with classic PTC and central lymph node metastasis and higher necessity of radioactive iodine ablation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Thyroidectomy
/
Thyroid Neoplasms
/
Exons
/
Risk Factors
/
Point Mutation
/
Real-Time Polymerase Chain Reaction
/
Mutation Rate
/
Iodine
/
Lymph Nodes
/
Neoplasm Metastasis
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
Language:
English
Journal:
Annals of Surgical Treatment and Research
Year:
2014
Type:
Article
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