Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea
Obstetrics & Gynecology Science
;
: 319-327, 2018.
Article
in English
| WPRIM
| ID: wpr-714712
ABSTRACT
OBJECTIVE:
Placental site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD) and the optimum management is still controversial. In this study, we analyzed the clinical features, treatment, and outcomes of 6 consecutive patients with PSTT treated in our institution.METHODS:
The electronic medical record database of Samsung Medical Center was screened to identify patients with PSTT from 1994 to 2017. Medical records for the details of each patient's clinical features and treatment were extracted and reviewed. This study was approved Institutional Review Board of our hospital.RESULTS:
A total of 418 cases of GTD, 6 (1.4%) patients with PSTT were identified. The median age of the patients was 31 years. The antecedent pregnancy was term in all 5 cases with available antecedent pregnancy information and the median interval from pregnancy to diagnosis of PSTT was 8 months. The median titer of serum beta human chorionic gonadotropin (β-hCG) at diagnosis was 190.9 mIU/mL. Five (83.3%) patients presented with irregular vaginal bleeding and one (16.7%) had amenorrhea. All patients had disease confined to the uterus without metastasis at diagnosis and were successfully treated by hysterectomy alone. All of them were alive without disease during the follow-up period.CONCLUSION:
In this study, we observed low level serum β-hCG titer and irregular vaginal bleeding with varying interval after antecedent term pregnancy were most common presenting features of PSTT. In addition, we demonstrated hysterectomy alone was successful for the treatment of stage I disease of PSTT.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Uterine Hemorrhage
/
Uterus
/
Medical Records
/
Follow-Up Studies
/
Trophoblastic Tumor, Placental Site
/
Ethics Committees, Research
/
Gestational Trophoblastic Disease
/
Diagnosis
/
Electronic Health Records
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Female
/
Humans
/
Pregnancy
Country/Region as subject:
Asia
Language:
English
Journal:
Obstetrics & Gynecology Science
Year:
2018
Type:
Article
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